All about Tadalafilo 5mg
Gui í a de Salud Masculina
Tadalafil (tadalafil) 5mg is a drug used to treat erectile dysfunction (ED) and lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). Here are the details:
I. Pharmacological action
1 、Mechanism of action on erectile dysfunction
Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor. Sexual stimulation promotes the release of nitric oxide (NO) from the nerve endings of the corpus cavernosum in men. NO activates guanylate cyclase and increases the production of cyclic guanosine monophosphate (cGMP).
-cGMP causes smooth muscle relaxation of the corpus cavernosum and blood flow into the cavernous sinus of the penis, which leads to erection, while PDE5 degrades cGMP. Tadalafil enhances erectile function by inhibiting the activity of PDE5 and reducing the degradation of cGMP.
2 、Mechanism of effect on lower urinary tract symptoms associated with benign prostatic hyperplasia
PDE5 enzyme also exists in the smooth muscle of prostate and bladder neck. After inhibiting PDE5, tadalafil can relax the smooth muscle of prostate and bladder neck and improve the symptoms of lower urinary tract in patients with benign prostatic hyperplasia, such as dysuria, frequent urination, urgent urination and so on.
II. Usage amount
1 、impotence
For most patients, the recommended starting dose for tadalafil is 10mg, which is taken before sex, and can be increased to 20mg or reduced to 5mg depending on individual efficacy and tolerance.
-the maximum frequency of taking medicine is once a day.
2 、Lower urinary tract symptoms associated with benign prostatic hyperplasia
-the recommended dose is 5mg, once a day, which can be adjusted according to the patient's symptoms and tolerance.
Third, adverse reactions
1 、Common adverse reactions
-headache, indigestion, back pain, myalgia, nasopharyngitis, flushing, etc., these adverse reactions are usually mild or moderate and will gradually alleviate or disappear after drug metabolism.
2 、Rare but serious adverse reactions
-Visual abnormalities may occur, such as color vision changes, blurred vision, etc., but this situation is relatively rare. If visual abnormalities occur, you should stop taking medication and seek medical treatment immediately.
IV. matters needing attention
1 、Use taboo
-Tadalafil is prohibited in patients who are taking any form of nitrates (such as nitroglycerin, isosorbide dinitrate), as nitrates in combination with tadalafil may cause a sharp drop in blood pressure and cause severe hypotension.
-it is forbidden for people who are allergic to tadarafi.
2 、Use by special groups
The elderlyOlder persons may not need to adjust the dose when using tadalafil, but since they tend to have multiple complications and take multiple drugs, drug interactions and adverse reactions need to be assessed more carefully.
Patients with hepatic and renal insufficiencyPatients with mild or moderate hepatorenal insufficiency may need to adjust the dose when using tadalafil. The safety and efficacy of tadalafil in patients with severe hepatorenal insufficiency have not been determined and should be used cautiously or avoided.