Tadalafil: All about the 20 Miligramos Dosage
Tadalafil is a drug used to treat related conditions such as erectile dysfunction (ED) in men. 20 mg is a common dosage strength.
1. Mechanism of action
1、Inhibition of PDE5
- Tadalafil mainly inhibits the activity of phosphodiesterase 5 (PDE5). In male penile corpus cavernosum tissue, sexual stimulation promotes the release of nitric oxide (NO) in the corpus cavernosum. NO activates guanylate cyclase and increases the level of cyclic guanosine monophosphate (cGMP), which leads to relaxation of smooth muscles and blood flows into the corpus cavernosum, triggering erection. PDE5 degrades cGMP. After tadalafil inhibits PDE5, it maintains the concentration of cGMP at a high level, which helps to maintain erectile function.
2. Precautions for use
1、usage
- Tadalafil 20-mg tablets are usually taken on demand before sexual activity, but there are also some low doses (such as 5 mg) that can be taken regularly daily. This usage may be more suitable for some patients who need frequent sexual activity. Help improve the vascular endothelial function of the corpus cavernosum of the penis.
2、contraindications
- Tadalafil is contraindicated for patients who are taking any form of organic nitrates (such as nitroglycerin, isosorbide mononitrate, etc.) because their combination may cause severe hypotension.
- It is contraindicated for people allergic to tadalafil.
3、adverse reactions
- Common adverse reactions include headache, facial flushing, indigestion, back pain, myalgia, etc. These adverse reactions are mostly mild to moderate and are usually transient.
4、special populations
- For the elderly (over 65 years of age), there is generally no need to adjust the initial dose, but it should be used with caution and closely observed for possible adverse reactions.
- In patients with renal dysfunction, dose adjustments may be required depending on the degree of renal impairment. For patients with mild or moderate renal dysfunction (creatinine clearance 30 - 80 mL/min), dose adjustments are not required; for patients with severe renal dysfunction (creatinine clearance 30 mL/min), the safety and effectiveness of use have not been determined and should be used with caution.
- Among patients with hepatic dysfunction, the maximum recommended dose is 10 mg for patients with mild or moderate hepatic dysfunction (Child-Pugh Class A or B) and should be used with caution; it is not recommended for patients with severe hepatic dysfunction (Child-Pugh Class C).
It should be emphasized that tadalafil is a prescription drug and must be used under the guidance of a doctor.