Tadalafil (Cialis) for Erectile Dysfunction: how it Works
tadalafil is a medicine that is used primarily to treat erectile dysfunction (ED) in men and can also be used in the treatment of benign prostate hypertrophy (BPH) with associated symptoms.
1. Mechanism of action
-Tadalafil inhibits the enzyme phosphodiesterase-5 (PDE-5). This enzyme is responsible for the degradation of nitrogen monoxide (no)-mediated cyclic monophosphate guanosin (cGMP) in the vascular smooth muscle of the penis. By inhibiting PDE-5, tadalafil increases cGMP levels, causing smooth muscle relaxation and increased blood flow to the penis, facilitating erection.
2. Dose and administration
-the 5 milligrams dose is one of the common doses available.
-it is usually taken by mouth, with or without food. However, absorption may be slightly slower when taken with a high fat meal.
-in the case of SD treatment, the action of tadalafil 5 mg can last up to 36 hours, which is known as the benefit of the "weekend". This means that a man can take the pill and have the possibility of a normal erection for a longer period compared to other drugs for ED.
-in the treatment of PPH, the dose and frequency of administration are determined according to the patient's symptoms and individual response.
3. Precautions and side effects
-precautions:
-it should not be taken in combination with nitrates, as interaction can cause a drastic drop in blood pressure, which can be dangerous.
-in patients with severe heart problems, risk and benefit should be carefully assessed before prescribing tadalafil.
-side effects:
-the most common side effects include headache, back pain, heartburn, nasal congestion, muscle and facial pain, and blush. These effects are usually mild to moderate and tend to disappear over time or with discontinuation of treatment.
It is important that tadalafil is prescribed and used under medical supervision, as each patient may have individual characteristics that affect their response and safety to the medication.