Tadalafila: What You Need to Know

What you want to ask may be "tadalafil" (Tadalafe).

I. Pharmacological action

1 、Mechanism of action

Tadalafil is a selective phosphodiesterase 5 (PDE5) inhibitor. PDE5 is highly expressed in corpus cavernosum smooth muscle cells and is responsible for the degradation of cyclic guanosine monophosphate (cGMP). When sexual stimulation induces the release of nitric oxide (NO), NO activates guanosine cyclase and converts guanosine triphosphate (GTP) into cGMP,cGMP, which relaxes the smooth muscle of the corpus cavernosum, and blood flows into the cavernous body of the penis, which leads to erection. Tadalafil enhances erectile function by inhibiting PDE5 and increasing the concentration of cGMP.

2 、Efficacy characteristics

Tadalafil acts for a relatively long time, commonly known as "long-acting" drugs for erectile dysfunction (ED). Compared with other PDE5 inhibitors such as sildenafil, tadalafil can be effective for about 36 hours, providing patients with a more flexible choice of sexual life.

II. Clinical application

1 、Treatment of erectile dysfunction (ED)

Tadalafil is a commonly used drug for the treatment of ED. Different doses can be selected according to the specific conditions of patients, such as the severity of the disease, age and other factors. The initial dose can be 10mg, and can be adjusted to 5mg or 20mg according to individual response and tolerance.

2 、Treatment of pulmonary hypertension (PAH) (under specific circumstances)

Tadalafil can dilate pulmonary vessels and reduce pulmonary vascular resistance, thereby improving symptoms and exercise tolerance in patients with pulmonary hypertension. The dose used in the treatment of pulmonary hypertension is different from that of ED and needs to be used under the strict monitoring of doctors.

III. Adverse reactions and matters needing attention

1 、Adverse reaction

Common adverse reactions include headache, facial flushing, indigestion, back pain, myalgia, etc. Most of these adverse reactions are mild and transient and can be relieved by themselves without special treatment.

-in rare cases, adverse reactions such as visual abnormalities (such as blurred vision, changes in color vision, etc.) and hearing loss may occur. If these conditions occur, you should seek medical advice in time.

2 、Matters needing attention

-patients who are taking any form of nitrate drugs (such as nitroglycerin, isosorbide dinitrate, etc.) are strictly prohibited from using tadalafil, as a combination of the two can lead to severe hypotension.

-patients with cardiovascular disease need to carefully assess the risk when using tadalafil, as erectile dysfunction itself may be an early warning sign of cardiovascular disease, and tadalafil may have an impact on the cardiovascular system in some cases.

Tadalafie does not apply to women and children.

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