Tadalafil 20mg: What You Need to Know

I. basic information on drugs

1 、Name and composition

-tadalafil (tadalafil) is a chemical, and 20mg is its common dose specification. Tadalafil is mainly used in the treatment of male erectile dysfunction (ED) and lower urinary tract symptoms caused by benign prostatic hyperplasia (BPH).

2 、Mechanism of action

Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor. During male erection, sexual stimulation promotes the release of nitric oxide (NO) in the penile cavernous body. NO activates guanosine cyclase and increases the level of cyclic guanosine monophosphate (cGMP), resulting in relaxation of corpus cavernosum smooth muscle, blood flow into the corpus cavernosum and erection, while PDE5 mainly exists in the corpus cavernosum smooth muscle cells of the penis. It can degrade cGMP. Tadalafil can increase the level of cGMP and enhance the erectile function of penis by inhibiting PDE5.

-in the treatment of benign prostatic hyperplasia, tadalafil can improve lower urinary tract symptoms by relaxing the smooth muscle of the prostate and bladder neck, such as improving urinary flow rate, reducing urination hesitation, increasing voiding volume, and so on.

II. Usage amount

1 、Treatment of erectile dysfunction (ED)

For most patients, the recommended initial dose of tadalafil is 10mg before sex. Depending on the efficacy and tolerance of the individual, the dose can be increased to 20mg or reduced to 5mg, with a maximum frequency of once a day.

-there are also some patients who take tadalafil regularly (take small doses daily). 20mg specifications can be properly divided according to the doctor's instructions, such as taking 5mg daily, which helps to improve the patient's spontaneous erectile function and has a better long-term effect on some patients with psychological ED or mild to moderate organic ED.

2 、Treatment of benign prostatic hyperplasia (BPH)

-the recommended dose is once a day, each 5mg, which may also be adjusted to 20mg if the doctor considers it appropriate after evaluation, but this is relatively rare and the patient's response needs to be closely monitored.

Matters needing attention

1 、Contraindication

-patients who are taking any form of nitrates (such as nitroglycerin, isosorbide dinitrate, etc.) prohibit tadalafil because nitrates in combination with tadalafil can lead to a sharp drop in blood pressure. can cause severe hypotension and even life-threatening symptoms.

-it is forbidden for people who are allergic to tadarafi.

2 、Adverse reaction

Common adverse reactions include headache, indigestion, back pain, myalgia, nasopharyngitis, facial flushing, etc., most of which are mild to moderate and usually temporary.

-in some rare cases, serious adverse reactions such as visual abnormalities (such as blue vision, green vision, etc.), hearing loss or loss may occur. Although the incidence rate is very low, medication should be stopped immediately and medical treatment should be sought if it occurs.

3 、Medication for special population

The elderlyWhen using tadalafil in the elderly, due to the possible decrease of liver and kidney function, it is generally necessary to start with a lower dose, and the adverse reactions need to be closely observed.

Patients with hepatic and renal insufficiencyIn patients with mild or moderate hepatorenal insufficiency, the dose of tadalafil may need to be adjusted. The safety and efficacy of tadalafil in patients with severe hepatorenal insufficiency are not clear and should be used cautiously or avoided.

When using tadalafil 20mg or other dose specifications, be sure to do so under the guidance of your doctor to ensure safety and effectiveness.