Tadalafil 20 mg (Cialis) for ED: precautions

tadalafil 20 mg is mainly used to treat two medical conditions:

1. Erectile dysfunction (DE)

Mechanism for action:

-Tadalafil inhibits the enzyme phosphodiesterase type 5 (PDE5). In the penis, the release of nitric oxide during sexual stimulation induces the production of cyclic monophosphate guanosin (cGMP), which causes relaxation of the smooth muscles of the penis and allows blood flow, resulting in an erection. PDE5 is responsible for degrading the cGMP. By inhibiting PDE5, tadalafil increases cGMP concentration, facilitating and improving erection.

Therapeutic effect:

-help men with SD achieve and maintain sufficient erections for sexual activity. It allows an improved erectile response to sexual stimulation, which can improve the quality of sexual life and sexual intercourse of patients.

2. Arterial pulmonary hypertension (HTAP)

Mechanism for action:

-in the pulmonary artery, PDE5 inhibition by tadalafil causes a relaxation of smooth arterial muscles. This decreases pulmonary vascular resistance, facilitating blood flow through the lungs. In addition, tadalafil may have anti-proliferative effects on vascular cells, which can help prevent or delay abnormal vascular remodeling in the pulmonary artery associated with HTAP.

Therapeutic effect:

-improves the cardiopulmonary capacity of patients with HTAP, relieving symptoms such as shortness of breath, fatigue and chest pain, and may also improve the survival and quality of life of these patients.

However, tadalafil should be prescribed by a doctor and its use should be followed according to medical indications and possible side effects should be considered.