Tadalafilo 20: Unveiling the Mysterious 20
Guía de Salud Masculina
"tadalafil 20" may refer to tadalafil tablets 20 mg.
1. Mechanism of Drug Action
1、PDE5 inhibitor
- Tadalafil is a selective phosphodiesterase 5 (PDE5) inhibitor. In male corpus cavernosum smooth muscle cells, PDE5 degrades cyclic guanosine (cGMP). By inhibiting PDE5, tadalafil reduces the degradation of cGMP, thereby increasing cGMP levels in corpus cavernosum smooth muscle cells.
- This causes smooth muscles to relax and blood to flow into the corpus cavernosum, which helps with penile erection and improves erectile dysfunction (ED).
2. Application
1、erectile dysfunction
- For men with erectile dysfunction, tadalafil 20 mg can be taken as needed before sexual activity, or according to a regular course of treatment (such as small daily doses) to improve erectile function.
2、Pulmonary arterial hypertension (PAH)
- In some cases, it can also be used to treat pulmonary arterial hypertension. It can relax pulmonary vascular smooth muscle and reduce pulmonary vascular resistance, thereby reducing the afterload on the right ventricle and improving the symptoms and exercise tolerance of patients with pulmonary arterial hypertension.
3. Matters needing attention
1、adverse reactions
- Common adverse reactions include headache, indigestion, back pain, muscle pain, flushing, etc. These adverse reactions are usually mild to moderate and will gradually diminish after the effects of the drug subside.
2、contraindications
- Tadalafil is strictly prohibited in patients who are taking any form of nitrates, such as nitroglycerin, because combination of the two may cause severe hypotension.
- Patients with severe cardiovascular diseases (such as unstable angina pectoris, recent myocardial infarction, etc.) need to carefully assess the risks when using it.