Tadalafil: Unraveling the Mysterious Tadafil?
Gui í a de Salud Masculina
tadalafil is a drug for the treatment of erectile dysfunction (ED) in men.
I. the mechanism of action
1 、Inhibition of PDE5 enzyme
-in the cavernous tissue of the male reproductive organs, there is an enzyme called phosphodiesterase 5 (PDE5). When a man is sexually stimulated, the nerve endings in the penile cavernous body release nitric oxide (NO).
-NO activates guanosine cyclase and converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP). CGMP relaxes the smooth muscle of the corpus cavernosum and causes blood to flow into the corpus cavernosum, resulting in penile erection.
Tadalafil, on the other hand, reduces the degradation of cGMP and maintains a high level of cGMP in the sponge by selectively inhibiting PDE5, which contributes to penile erection and maintenance of erection.
II. Characteristics of drugs
1 、Long-term effect
Compared with some other drugs for ED, tadalafil lasts longer and can be effective for about 36 hours, which means that within a longer time window after taking the drug, patients are likely to have a normal erection when they are sexually stimulated, providing patients with a more flexible schedule of sexual life.
2 、Absorption and dietary influence
The absorption of tadalafil is not affected by food. Patients can take it on an empty stomach or eating. After oral administration, tadalafil is quickly absorbed and usually reaches the plasma peak concentration in about 2 hours.
Matters needing attention in use
1 、intended for
-it is mainly suitable for adult male patients with erectile dysfunction, but before using it, doctors should conduct a comprehensive evaluation to rule out other serious underlying diseases that may lead to erectile dysfunction, such as cardiovascular disease, endocrine disease and so on.
2 、Contraindication
-patients who are taking any form of nitrates (such as nitroglycerin, isosorbide dinitrate, etc.) prohibit tadalafil because tadalafil in combination with nitrates can lead to a sharp drop in blood pressure, which can cause severe symptoms of hypotension and even life-threatening.
-Women, children and people who are not allergic to tadala should not use the drug.
3 、Adverse reaction
Common adverse reactions include headache, facial flushing, indigestion, nasal congestion, muscle pain, etc. Most of these adverse reactions are mild and transient and usually relieve themselves after drug metabolism, but if the adverse reactions persist or worsen, you should seek medical attention in time.
Tadalafil should be used reasonably under the guidance of doctors to ensure the safety and effectiveness of medication.